About Setting 1

Setting 1 evaluates the impact of ENHANCED TREATMENT interventions (against HAI) on patient outcomes across varying α and β values.

α is the effect of ENHANCED TREATMENT interventions on DISCHARGE and β on DEATH (See formulas attached to Setting 1 Figure).

α and β range from 0 to 1, where 1 indicates no treatment effect (minimal effect) and 0 represents the maximum treatment effect.

Transition Hazard Rate (λᵢⱼ): This defines the rate at which patients move from state i to state j.

λᵢⱼ = (Number of transitions from state i to state j) ÷ (Total patient-days in state i).

Reduced mortality rate calculated for specified α and β values and displayed in the plots (e.g. RM=0.05)
Number of lives saved per population unit, calculated for specified α and β values and displayed in the plots (e.g. 50 per 1,000 patients) / Note: Lives Saved = Reduced Mortality × Total number of Patients
Change in hospital length of stay relative to baseline, calculated for specified α and β values and displayed in the plots (e.g. C_LoS=2.5days)
Total reduction in patient‑days calculated for specified α and β values and displayed in the plots (e.g. 250 patient‑days) / Note: Patient-Days Reduced = Change in Length of Stay × Total number of Patients

About Setting 2

Setting 2 evaluates the impact of ENHANCED TREATMENT and INFECTION PREVENTION interventions on patient outcomes across varying α, β and θ values.

α is the effect of ENHANCED TREATMENT interventions on DISCHARGE and β on DEATH.

θ is the IMPROVED INFECTION PREVENTION factor.

α, β and θ range from 0 to 1, where 1 indicates no treatment effect (minimal effect) and 0 represents the maximum treatment effect.

Transition Hazard Rate (λᵢⱼ): This defines the rate at which patients move from state i to state j.

λᵢⱼ = (Number of transitions from state i to state j) ÷ (Total patient-days in state i).